Dr. Jaime Ortega López

Investigador Titular 3C.

PhD, 24/03/1995, Biochemistry. Graduate School of Biomedical Sciences. University of Texas Health Science Center at San Antonio, U.S.A.

M. en C. 16/06/1986. Departamento de Biotecnología y Bioingeniería, CINVESTAV-IPN. México, D.F. 16 de Julio de 1986.

I.Q., 30/06/1982. Facultad de Ciencias Químicas, Universidad de Guadalajara, Jalisco, México.

Investigador Nacional Nivel II


jortega@cinvestav.mx
Tel. +52 (55) 57473800 Ext.4381 y 4368
 

Replegamiento cromatográfico de proteínas recombinantes aprovechando la afinidad del dominio de unión a celulosa.

Expresión, purificación y caracterización bioquímica de cisteín-proteinasas de Trichomonas vaginalis y Entamoeba histolytica.

Efecto del medio y condiciones de cultivo en la producción de una vacuna de ADN contra leishmaniasis.

  • Mejia-Castillo T, Hidalgo-Lara ME, Brieba LG, Ortega-Lopez J: Purification, characterization and modular organization of a cellulose-binding protein, CBP105, a processive beta-1,4-endoglucanase from Cellulomonas flavigena. Biotechnol Lett 2008, 30:681-687.
     
  • Solano-Gonzalez E, Burrola-Barraza E, Leon-Sicairos C, Avila-Gonzalez L, Gutierrez-Escolano L, Ortega-Lopez J, Arroyo R: The trichomonad cysteine proteinase TVCP4 transcript contains an iron-responsive element. FEBS Lett 2007, 581:2919-2928.
     
  • Montesinos-Cisneros RM, Olivas JDLV, Ortega J, Guzmán R, Tejeda-Mansir A: Breakthrough performance of plasmid DNA on ion-exchange membrane columns. Biotechnology Progress 2007, 23:881-887.
     
  • Solano-Gonzalez E, Alvarez-Sanchez ME, Avila-Gonzalez L, Rodriguez-Vargas VH, Arroyo R, Ortega-Lopez J: Location of the cell-binding domain of CP65, a 65kDa cysteine proteinase involved in Trichomonas vaginalis cytotoxicity. Int J Biochem Cell Biol 2006, 38:2114-2127.
     
  • Ramon-Luing LA, Cruz-Migoni A , Ruiz-Medrano R, Xoconostle-Cazares B, Ortega-Lopez J: One-step purification and immobilization in cellulose of the GroEL apical domain fused to a carbohydrate-binding module and its use in protein refolding. Biotechnol Lett 2006, 28:301-307.
     
  • Montesinos-Cisneros RM, Ortega J, Guzmán R, Tejeda-Mansir A: Breakthrough performance of linear-DNA on ion-exchange membrane columns. Bioprocess and Biosystems Engineering 2006, 29:91-98.
     
  • Ocadiz R, Orozco E, Carrillo E, Quintas LI, Ortega-Lopez J, Garcia-Perez RM, Sanchez T, Castillo-Juarez BA, Garcia-Rivera G, Rodriguez MA: EhCP112 is an Entamoeba histolytica secreted cysteine protease that may be involved in the parasite-virulence. Cell Microbiol 2005, 7:221-232.
     
  • Leon-Felix J, Ortega-Lopez J, Orozco-Solis R, Arroyo R: Two novel asparaginyl endopeptidase-like cysteine proteinases from the protist Trichomonas vaginalis: their evolutionary relationship within the clan CD cysteine proteinases. Gene 2004, 335:25-35.
     
  • Musatov A, Ortega-Lopez J, Robinson NC: Detergent-solubilized bovine cytochrome c oxidase: Dimerization depends on the amphiphilic environment. Biochemistry 2000, 39:12996-13004.
     
  • Mendoza-Lopez MR, Becerril-Garcia C, Fattel-Facenda LV, Avila-Gonzalez L, Ruiz-Tachiquin ME, Ortega-Lopez J, Arroyo R: CP30, a cysteine proteinase involved in Trichomonas vaginalis cytoadherence. Infection and Immunity 2000, 68:4907-4912.
     
  • Alvarez-Sanchez ME, Avila-Gonzalez L, Becerril-Garcia C, Fattel-Facenda LV, Ortega-Lopez J, Arroyo R: A novel cysteine proteinase (CP65) of Trichomonas vaginalis involved in cytotoxicity. Microb Pathog 2000, 28:193-202.